教学工作

药物分析

高等药物分析

现代药物分析技术

研究领域

高效微流电动分离分析仪器研发及其研究；

新型分离介质和毛细管整体柱的制备及在毛细管电色谱中的应用；

代谢组学研究；

药物质量控制及复杂体系分离分析；

食品安全及食品分析。

项目

1. 2011-01-01～2014-01-01;国家重大科学仪器专项——高效微流电色谱分析仪器的开发与应用.

2. 2012-01-01～2015-12-01;蒸发光散射检测器的微型化及其与加压毛细管电色谱联用的研究.

3. 2012-01-01～2015-12-01;微型微流CCD紫外/可见柱上检测仪的研制及其与毛细管分离技术的联用.

专利

1. Chao Yan;Multiuse pressure electric chromatographic device;专利号：US006569325B1.

2. Chao Yan;Electrokinetic packing of capillary columns;专利号：US005453163A.

3. Chao Yan;Electro-osmotically driven liquid delivery method and apparatus;专利号：US005942093A.

4. 阎超；乔燕燕；戈兆松;高灵敏度荧光检测装置;专利号：ZL20061 0147285.7.

5. 阎超；王建民；俞晓勇;增强型光信号检测系统;专利号：ZL 2009 1 0057346.4.

6. 阎超；彭章晓；王彦；温元元;木香药物组合物及其医药用途;专利号：ZL 2012 1 0185071.4.

7. 阎超；王玉红；王建民;蒸发光散射检测装置;专利号：ZL 2011 1 0137925.7.

8. 上海交通大学;富含有机苯硼酸的聚乙烯亚胺修饰的二氧化硅微球及其制备方法和应用;专利号：201410356775.2.

9. 上海交通大学;一种压力毛细管电色谱质谱接口装置;专利号：201410368081.0.

10. 上海交通大学;一种亚微米无孔环糊精键合手性毛细管柱的制备;专利号：201410356144.0.

11. 王彦；彭章晓；阎超；章雪；李栋；薛云；宁慧；姚凯；周君裔;实验鼠代谢笼;专利号：ZL 2012 2 0265580.3.

12. 阎超；高红秀；王玉红;一种微流蒸发光散射检测装置;专利号：ZL 2013 2 0602743.7.

13. 阎超、王玉红;加压毛细管电色谱蒸发光散射检测器;专利号：ZL201110137932.7.

14. 阎超、姚凡;并行双光路激光诱导荧光光谱仪;专利号：ZL201310175301.3.

15. 阎超;全自动高精度毛细管电泳仪;专利号：PCT/CN2014/000473.

16. 阎超;串行双光路激光诱导荧光光谱仪;专利号：PCT/CN2014/000472.

17. 阎超、姚冬、张琳;全自动高精度毛细管电泳仪;专利号：201410108667.3.

18. 阎超、姚凡;串行双光路激光诱导荧光光谱仪;专利号：201310175950.3.

19. 阎超、李静;一种石墨烯修饰毛细管色谱柱的制备方法;专利号：201310012747.4.

20. 阎超;蒸发光散射检测器的鞘流装置;专利号：201410437831.5.

21. 阎超,茹鑫;可视化校准激光诱导荧光检测器设备;专利号：201410741826.3.

22. 阎超;一种加压毛细管电色谱质谱接口装置;专利号：201410368081.0.

23. 阎超;一种石墨烯修饰毛细管色谱柱的制备方法;专利号：201310012747.4.

24. 一种制备核壳型颗粒的方法及其制得的核壳型颗粒的用途;专利号：201410369538X.

25. 阎超、王建民;微量液体进样阀;专利号：ZL200420020810.5.

26. 阎超;一种定量进样毛细管电泳装置;专利号：ZL200420020809.2.

27. 阎超、黄晓晶;定量高精度毛细管电泳仪;专利号：ZL200520040700.X.

28. 阎超、戈兆松、于立民;激光诱导荧光检测器检测槽(LIF);专利号：ZL200520048181.1.

29. 阎超、于立民、王建民;一种蒸发光散射检测器的冷凝管结构;专利号：ZL200620043547.0.

30. 阎超、乔燕燕、戈兆松;高灵敏度荧光检测器的波长带宽调节装置;专利号：ZL200620049006.9.

31. 阎超、姚冬、张琳;全自动高精度毛细管电泳仪;专利号：ZL201420131764.X.

32. 阎超、乔燕燕、林泽涛;一种新型加压毛细管电色谱装置;专利号：ZL200720071407.9.

33. 阎超、王玉红、林泽涛、李鹏;一种多维色谱联用分离装置;专利号：ZL200820157969.X.

34. 阎超,茹鑫;激光诱导荧光检测器;专利号：ZL201420764920.6.

35. 阎超、乔燕燕;一种微弱光增强信号检测装置;专利号：201120213869.6.

36. 阎超、王建民;一种蒸发光散射检测器的微弱光会聚系统;专利号：201120213854.X.

37. 阎超;全自动定量毛细管电泳仪的液体输送系统;专利号：201420538174.9.

38. 阎超;具有会聚包裹作用的鞘流装置;专利号：ZL201420496932.5.

39. 阎超;一种加热装置;专利号：ZL201320533869.3.

40. 阎超;一种简易输液装置;专利号：ZL201320533868.9.

41. 阎超;液相色谱系统;专利号：ZL201420083570.7.

42. 阎超、李静;高效液相色谱柱;专利号：ZL201420083724.2.

43. 阎超、李静;一种毛细管用电加热装置;专利号：ZL201420072641.3.

44. 阎超、于立民、乔燕燕、李昭;一种蒸发光散射检测器的光束会聚系统;专利号：ZL200620040574.2.

45. 阎超、林泽涛、乔燕燕;一种用于加压毛细管电色谱系统的信号转换装置;专利号：ZL200720071406.4.

46. 一种毛细管柱;专利号：ZL201420081674.4.

论文

1. Comprehensive ultra-performance liquid chromatographic separationand mass spectrometric analysis of eicosanoid metabolites in human samples.Yan Wang, Aaron M. Armando, Oswald Quehenberger, Chao Yan*, Edward A. Dennis.Journal of Chromatography A,2014.

2. Metabolic transformation of breast cancer in a MCF-7 xenograft mouse model and inhibitory effect of volatile oil from Saussurea lappa Decne treatment.Zhang-xiao Peng, Yan Wang, Xue Gu,Yun Xue, Qian Wu, Jun-yi Zhou，Chao Yan*.Metabolomics,2014.

3. Pressurized CEC coupled with QTOF-MS for urinary metabolomics.Qian Wu, Xinwei Yu, Yan Wang, Xue Gu, Xiaoqiong Ma, Wang Lv, Zhe Chen, Chao Yan*.Electrophoresis,2014.

4. Serum metabolite profiling of B-cell non-Hodgkin’s lymphoma using UPLC-QTOFMS and GC-TOFMS.Junyi Zhou, Shijun Yu , Yan Wang, Xue Gu, Qian Wu, Yun Xue, Gao Shan, Huiping Zhang, Weili Zhao, Chao Yan*.Metabolomics,2014.

5. Metabolomic profiling of human plasma in pancreatic cancer using pressurized capillary electrochromatography.Huiping Zhang, Yan Wang Xue Gu, Junyi Zhou, Chao Yan*a.Electrophoresis,2011.

6. Urinary metabolomic study of non-small cell lung carcinoma based on ultra high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry.Qian Wu1, Yan Wang1, Xue Gu1, Junyi Zhou1, Huiping Zhang1, Wang Lv2, Zhe Chen2,* andChao Yan1,*.Journal of Separation Science,2014.

7. Solid-phase extraction approach for phospholipids profiling by titania-coated silica microspheres prior to reversed-phase liquid chromatography-evaporative light scattering detection and tandem mass spectrometry analysis.Juan Bian, Yun Xue, Kai Yao, Xue Gu, Chao Yan, Yan Wang.Talanta,2014.

8. Two-dimensional separation system by on-line hyphenation of capillary isoelectric focusing with pressurized capillary electrochromatography for peptide and protein mapping.Wei Juan, Gu Xue, Wang Yan, Wu Yi, Yan Chao.ELECTROPHORESIS,2011.

9. Silica spheres coated with C18-modified gold nanoparticles for capillary LC and pressurized CEC separations.Juan Wei, Xue Gu, Yan Wang, Yi Wu, Chao Yan* .Electrophoresis,2011.

10. Monolithic silica xerogel capillary column for separations in capillary LC and pressurized CEC.Qi shu Qu, Song Wang, Debby Mangelings, Cheng yin Wang, Gong jun Yang, Xiao ya Hu, Chao Yan.ELECTROPHORESIS,2009.

11. Capillary electrochromatography of molecularly imprinted monolithic column using p-hydroxybenzoic acid as templates.ZhaoSheng Liu, YanLi Xu, Chao Yan, RuYu Gao.CHINESE CHEMICAL LETTERS,2004.

12. Preparation and evaluation of a series of reversed-phase monolithic columns for capillary electrochromatography.Kai Zhang , Chao Yan & Ruyu Gao.ANALYTICAL LETTERS,2004.

13. Chiral separation of binaphthol enantiomers on molecularly imprinted polymer monolith by capillary electrochromatography.ZhaoSheng Liu, YanLi Xu, Chao Yan, RuYu Gao.ANALYTICAL SCIENCES,2004.

14. Preparation and characterization of molecularly imprinted monolithic column based on 4-hydroxybenzoic acid for the molecular recognition in capillary electrochromatography.ZhaoSheng Liu, YanLi Xu, Chao Yan, RuYu Gao.Analytica Chimica Acta,2004.

15. Pressurized electrochromatography coupled with electrospray ionization mass spectrometry for analysis of peptides and proteins.6. Zhen Liang, Jicheng Duan, Lihua Zhang, Weibing Zhang, Yukui Zhang, Chao Yan*,.ANALYTICAL CHEMISTRY,2004.

16. Separation of peptides by pressurized capillary electrochromatography.Kai Zhang, Chao Yan, Zhichao Zhang, Qinsun Wang, Ruyu Gao,.CHINESE CHEMICAL LETTERS,2003.

17. Mixed Mode of Hydrophilic and Ionic Interaction Pressurized Capillary Electrochromatography for Separation of Basic Compounds.Kai Zhang, Chao Yan, Zhichao Zhang, Qinsun Wang, Ruyu Gao,.JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES,2003.

18. Cinnamic acid polymer-based monolithic column for capillary electrochromatography.Weiying Yan, Ruyu Gao, Zhichao Zhang, Chao Yan, Qingsun Wang,.CHROMATOGRAPHIA,2003.

19. Pressurized capillary electrochromatography separation of peptides with strong cation exchange and hydrophilic interaction.13. Kai Zhang, Ruyu Gao, Zhengjin Jiang, Chuanyi Yao, Zhichao Zhang, Qinsun Wang,.JOURNAL OF SEPARATION SCIENCE,2003.

20. Quantitative sample injection for capillary electrophoresis.Chuanyi Yao, Ruyu Gao, Chao Yan*.JOURNAL OF SEPARATION SCIENCE,2003.

21. Capillary electrochromatographic separation of ionizable compounds with a molecular imprinted monolithic cationic exchange column.Weiying Yan, Ruyu Gao, Chao Yan*,.JOURNAL OF SEPARATION SCIENCE,2003.

22. Sepatation of peptides by pressurized capillary electrochromatoraphy.Kai Zhang, Chao Yan, Chuanyi Yao, Ruyu Gao,.JOURNAL OF CHROMATOGRAPHY A,2003.

23. Short, highly cross-linked, polymer based, monolithic column for capillary electrochromatography.Weiying Yan, Zhichao Zhang, Ruyu Gao, Chao Yan, Qinsun Wang.JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES,2002.

24. Development of a precolumn derivatization method for the determination of free amines in wastewater by high-performance liquid chromatography via fluorescent detection with 9-(2-hydroxyethyl)acridone.20. Jinmao You, Weibing Zhang, Qinghe Zhang, Lin Zhang, Chao Yan, Yukui Zhang,.ANALYTICAL CHEMISTRY,2002.

25. Enantiomeric separations of 1-1,2,4-triazole compounds by micro-high performance liquid chromatography.Wei Wei Luo, Guoan, Chao Yan*,.Se pu,2001.

26. Calculation of retention factors for charged solutes in capillary electrochromatography.Wei Wei Luo, Guoan, Chao Yan*,.JOURNAL OF SEPARATION SCIENCE,2001.

27. Separation of pyridazinone derivatives using pressurized gradient capillary electrochromatography.Zhengjin Jiang, Ruyu Gao, Yibo Zhou, Zhichao Zhang, Qinsun Wang, Chao Yan*,.JOURNAL OF MICROCOLUMN SEPARATIONS,2001.

28. Pressurized gradient capillary electrochromatographic separation of eighteen amino acid derivatives.Ru, Q.-H.; Yao, J.; Guo’an Luo, Zhang, Y.-X.; Chao Yan*,.JOURNAL OF CHROMATOGRAPHY A,2000.

29. Separation of related opiate compounds using capillary electrochromatography.Jong Tae Lim, Richard N Zare, Christopher G Bailey, David J Rakestraw, Chao Yan*,. Electrophoresis,2000.

30. Determination of sulfonylurea herbicides by capillary electrochromatography.Viorica Lopez-Avila, Janet Benedicto, Chao Yan*,.Journal of Chromatographic Science,1999.

31. Enantiomer separations of phenylephrine and synephrine by capillary electrochromatography on bare silica stationary phase using hydroxypropyl-beta-cyclodextrin as a mobile phase additive.Wei Wei, Guoan Luo, Rong Xiang, Chao Yan*,.JOURNAL OF MICROCOLUMN SEPARATIONS,1999.

32. Sensitive, universal detection for capillary electrochromatography using condensation nucleation light scattering detection.Wei Guo, J. A. Koropchak, Chao Yan*,.JOURNAL OF CHROMATOGRAPHY A,1999.

33. Enantiomeric separation of beta-amino alcohols by capillary electrophoresis using DM-beta-CD as chiral selector.Wei Wei, Guoan Luo, Chao Yan, Zengpei Sun,.HRC-JOURNAL OF HIGH RESOLUTION CHROMATOGRAPHY,1998.

34. Ion-exchange capillary electrochromatography with a strong cation exchanger packed column.Wei Wei, Guo’an Luo, Chao Yan*,.AMERICAN LABORATORY,1998.

35. Study on the pharmacokinetics and metabolism of costunolide and dehydrocostus lactone in rats by HPLC-UV and UPLC-Q-TOF/MS.Zhangxiao Peng, Yan Wang, Xue Gu, Xiaojie Guo, Chao Yan*.Biomedical Chromatography,2014.

36. Retention prediction based on the solvatochromic comparison method in reversed-phase capillary electrochromatography.Wei Wei, Yiming Wang, G.uo’an Luo, Chao Yan*.JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES,1998.

37. Capillary electrochromatographic separation of basic compounds with bare silica as stationary phase.Wei Wei, Guoan Luo, Chao Yan*.JOURNAL OF CHROMATOGRAPHY A,1998.

38. Separation of explosives using capillary electrochromatography.Christopher G Bailey, Yan Chao*,.ANALYTICAL CHEMISTRY,1998.

39. Advances in capillary electrochromatography: Rapid and high-efficiency separations of PAHs.Rajeev Dadoo, Richard N Zare, Deon S Anex, Chao Yan*,.ANALYTICAL CHEMISTRY,1998.

40. Determination of selected heterocyclic compounds containing nitrogen, oxygen, and sulfur by capillary electrochromatography.Viorica Lopez-Avila, Janet Benedicto, Chao Yan*,.JOURNAL OF HIGH RESOLUTION CHROMATOGRAPHY,1997.

41. Advances toward the routine use of capillary electrochromatography.Rajeev Dadoo, Chao Yan, Richard N Zare, Deon S Anex, David J Rakestraw, Gary A Hux,.LC GC-MAGAZINE OF SEPARATION SCIENCE,1997.

42. Selectivity tuning in pressurized capillary electrochromatography with a zwitterionic monolithic column.Ray H. Yan, Ye Gao, Xiaochun Wang, Xiaohui Zhang, Chao Yan*, Yan Wang.Journal of Chromatographic Science,2013.

43. A platform for fast screening potential anti-breast cancer compounds in traditional Chinese medicines.Zhangxiao Peng, Yan Wang, Xue Gu, Yuanyuan Wen, Chao Yan*.Biomedical Chromatography,2013.

44. GRP78 and GAL3, differentially regulated by lymph node homogenates, as potential biomarkers for lymph node metastasis in mouse hepatocellular carcinoma cells.Zhu WJ, Owusu L, Zang SZ, Zhang YJ, Xin Y, Yan C*.Oncology Letters,2012.

45. Preparation of a monolith with covalently bound bovine serum albumin for capillary electrochromatography.Yao CY, Tang SK, Yan C. *.Analytical Letters,2012.

46. Gradient elution in capillary electrochromatography.Chao Yan, Rajeev Dadoo, Richard N Zare, David J Rakestraw, Deon S Anex,.Analytical chemistry,1996.

47. Automated capillary electrochromatography: reliability and reproducibility studies.Maria T Dulay, Chao Yan, David J Rakestraw, Richard N Zare,.Journal of Chromatography A,1996.

48. Capillary electrochromatographic testing of monolithic silica columns synthesized according to an experimental design approach.Xiaoping Wu, Debby Mangelings, Iuliana Oita, Indiana Tanret, Chao Yan*.Journal of Separation Science,2011.

49. Capillary electrochromatography: operating characteristics and enantiomeric separations.Frederic Lelievre, Chao Yan, Richard N Zare,.Journal of Chromatography A,1996.

50. Capillary Electrochromatography: Analysis of Polycyclic Aromatic Hydrocarbons.Chao Yan, Rajeev Dadoo, Hui Zhao, Richard N Zare, David Rakestraw,.Analytical chemistry,1995.