研究领域

1.通过对生物合成途径的重构，设计新结构、高活性的杂合抗生素。

2.从微生物次级代谢产物中筛选活性先导化合物。

3.利用关键的基因单元挖掘技术，从微生物中寻找新的活性先导化合物。

论文

1. A Novel Phytotoxic Nonenolide from Phomopsis sp. HCCB03520.Zhijun Yang, Yu Yin, Yi Chen, Daijie Chen.Chemistry & Biodiversity.

2. Improvement of spinosad production by overexpression of gtt and gdh controlled by promoter PermE* in Saccharopolyspora spinosa SIPI-A2090.Hai-Xue Pan, Ji-An Li, Ning-Jun He, Ji-Ye Chen, Yu-Meng Zhou, Lei Shao, Dai-Jie Chen.Biotechnol Lett.

3. Overexpression of aveBIV leading to the improvement of 4′-epidaunorubicin production in Streptomyces coeruleorubidus strain SIPI-A0707 Appl.Lei Shao, Jia Huang, Lan Jing, Ji-Ye Chen, Shi-Dong Kan, Min Wang, Ji-An Li, Dai-Jie Chen.Microbiol Biotechnol.

4. Molecular cloning and sequence analysis of the sisomicin biosynthetic gene cluster from Micromonospora inyoensis.Wen-Rong Hong，Mei Ge，Zhi-Hong Zeng，Li Zhu，Min-Yu Luo，Lei Shao，Daijie Chen.Biotechnol Lett.

5. Purification an characterization of a novel fibrinolytic protease from Fusarium sp. CPCC 480097. J Ind.Bin Wu, Licheng Wu, Daijie Chen, Zhijun Yang, Minyu Luo.Microbiol Biotechnol.

6. Screening of Endophytic Fungi with Antithrombotic Activity and Identification of a Bioactive Metabolite from the Endophytic Fungal Strain CPCC 480097..Bin Wu, Licheng Wu, Lingao Ruan, Mei Ge, Daijie Chen.Curr Microbiol.

7. Microsphere resin chromatography combined with microbial biotranformation for separation and purification of salvianic acid B in aqueous extract of roots of Salvia multiorrihza Bunge.Shidong Kan, Ji-an Li ,Weiyi Huang, Lei Sha, Daijie Chen.Journal of Chromatography A.

8. Thiopeptide Biosynthesis Featuring Ribosomally Synthesized Precursor Peptides and Conserved Posttranslational Modifications.Rijing Liao,Lian Duan, Chun Lei,Haixue Pan, Ying Ding, Qi Zhang, Daijie Chen, Ben Shen, Yi Yu, and Wen Liu.Chemistry & Biology.