分子酶学与合成生物学研究室负责人是冯雁教授，研究团队由4名教师、2名工作人员、20余名研究生及约10名本科生组成。
实验室主要开展重要功能酶的结构-功能关系、酶分子进化和人工催化体系构建等研究，具有多学科（分子生物学、微生物学、生物化学、化学生物学、合成生物学等）交 叉特点。在揭示天然酶结构-功能关系的基础上，发展蛋白质工程技术，实现对酶功能的再设计，提高酶对特定底物的选择性、催化效率和对环境的适应性等；并基 于合成生物学理念，对微生物药物合成途径重新编程，并对关键酶进行优化设计，建立药物合成的新途径。
专利
冯雁，张宇，安娇，杨广宇;磷酸三酯酶突变体及其制备方法和应用;专利号：201210015096.2.
冯雁，田东升，杨广宇，安娇，谢渊，白挨玺;嗜热内切木聚糖酶基因工程菌的构建及其酶的应用;专利号：201110406838.7.
冯雁，谢渊，杨广宇;热稳定性提高的脂肪酶突变体及其构建方法;专利号：201110406922.9.
冯雁，王元鸿，王蕊，李全顺;以酸酐为酰基供体制备手性脂肪醇的方法;专利号：ZL200710055455.3.
冯雁，马玖彤，李全顺，宋博;新型超嗜热酯酶催化制备聚（ε-己内酯）的方法;专利号：ZL200710055456.8.
论文
Ring-opening polymerization of ε-caprolactone catalyzed by a novel thermophilic lipase from Fervidobacterium nodosum.Quanshun Li, Shanshan Yu, Fuqiang Ma, Yan Feng.Process Biochem,2011.
Highly efficient ring-opening polymerization of ε-caprolactone catalyzed by a recombinant Escherichia coli whole-cell biocatalyst.Quanshun Li Guangquan Li, Fuqiang Ma, Zuoming Zhang, Baisong Zheng and Yan Feng.Process Biochem,2011.
Experimental and computational studies indicate the mutation of Glu12 to increase the thermostability of oligomeric protease from Pyrococcus horikoshii.Dongling Zhan, Weiwei Han, Yan Feng.J Mol Model,2011.
Fervidobacterium changbaicum Lip1: identification, cloning, and characterization of the thermophilic lipase as a new member of bacterial lipase family V.Jingang Cai, Yuan Xie, Bo Song, Yanping Wang, Zuoming Zhang, Yan Feng.Appl Microbiol Biotechnol,2011.
Quantitative investigation of non-hydrolytic disruptive activity on crystalline cellulose and application to recombinant swollenin.Yuguo Wang, Rentao Tang, Jin Tao, Gui Gao, Xiaonan Wang, Ying Mu, Yan Feng.Appl Microbiol Biotechnol,2011.
Switch of substrate specificity of hyperthermophilic acylaminoacyl peptidase by combination of protein and solvent engineering.Chang Liu, Guangyu Yang, Lie Wu, Guohe Tian, Zuoming Zhang, Yan Feng.Protein Cell,2011.
Chimeric Cellulase Matrix for Investigating Intramolecular Synergism between Non-hydrolytic Disruptive Functions of Carbohydrate-binding Modules and Catalytic Hydrolysis.Yuguo Wang, Rentao Tang, Jin Tao, Xiaonan Wang, Baisong Zheng, Yan Feng.J Biol Chem,2012.